|
In 1939 Scott and Robb-Smith proposed histiocytic medullary reticulosis as a definite clinicopathologic entity. Since their original report, approximately 60 cases have been reported in the literatures. The disease occurs in adults, and is rapidly fatal, generally characterized by wasting, fever, scattered lym phadenopathy, hepatomegaly, splenomegaly, anemia, and often accompanied by jaundice, purp a and leukopenia. Microscopically there is diffuse proliferation of histiocytes and its precursors, often of abnormal structure and often with marked erythrophagocytosis in lymph nodes, spleen, liver and bone arrow. No definite case of histicytic medullary, reticulosis was reported in this country. Recently we had the opportunity to observe a patient at. Severance Hospital, whose clinical course and, post mortem pathological features were,consistent with criteria for the disease. The purpose of this report is to illustrate; pertinent clinical and morphologic features of this case, and to review the cases reported in previous.eliteratures.
|